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Yellow vest motion: A whole lot arrested – NEWPAPER24

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Yellow vest motion: A whole lot arrested

2018-12-08 16:38:12

Police in Paris have fired tear fuel on protesters as a fourth weekend of anti-government protests turned violent.

The clashes got here after as much as 8,000 demonstrators gathered within the metropolis centre. Greater than 500 folks have been taken into custody.

Police informed the Newpaper24 that 30 folks have been injured within the capital, together with three cops.

The “yellow vest” motion opposed gas tax rises however ministers say it has been hijacked by “ultra-violent” protesters.

Round 8,000 police and 12 armoured automobiles have been deployed in Paris, and practically 90,000 countrywide.

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Breast most cancers testing genetic tips outdated, says examine – NEWPAPER24

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Breast most cancers testing genetic tips outdated, says examine

2018-12-10 20:07:11

The outcome: Sufferers with out genetic take a look at outcomes may not obtain the suitable therapy for his or her most cancers, which could possibly be a matter of life or dying.

Roughly 330,000 sufferers are identified with breast most cancers yearly in the US and of those circumstances, an estimated 10% are seemingly because of hereditary causes, in accordance with Beitsch.

The rules for the genetic testing of breast most cancers sufferers had been established about 20 years in the past by the Nationwide Complete Most cancers Community, a nonprofit alliance of 28 most cancers facilities devoted to enhancing affected person care, defined Beitsch, who’s a co-founder of the TME Breast Care Community, a nonprofit centered solely on advancing therapy for breast most cancers sufferers.
“Again then we examined for 2 genes, BRCA1 and BRCA 2,” stated Beitsch. BRCA 1 and BRCA 2 are tumor suppressor genes that everybody has; if a defect or mutation happens in a single or each of those genes, the chance of breast most cancers is elevated. “Genetic testing was extremely troublesome to do and costly; it value about $5,000 to simply take a look at the 2 genes,” he defined. The rules, then, “originated actually as an financial roadblock to attempt to lower the general value of well being care in America,” he stated.

Since then it has develop into identified that 11 “main” gene mutations, together with BRCA 1 and BRCA 2, could cause breast most cancers, whereas 25 or 30 different genetic variants are additionally linked to the illness, stated Beitsch.

In the meantime, genetic testing “radically modified. It went from a difficult-to-do, and costly, take a look at to a fairly cheap take a look at,” stated Beitsch. “The price dropped from, say, $5,000 for 2 genes to now we’re doing 80 genes for about $250.”

Whereas the rules additionally advanced, they “obtained extremely sophisticated,” he stated: “unusable.”

So Beitsch and his colleagues arrange a examine to take a look at almost a thousand feminine breast most cancers sufferers, half who met the standards set forth within the Nationwide Complete Most cancers Community tips, the opposite half who didn’t. Amongst 959 examine members, all underwent a full panel of DNA testing for hereditary breast most cancers.

The outcomes confirmed that 83 ladies or 8.65% of the entire members, had breast cancer-linked genetic defects. Of those, 45 ladies met the Nationwide Complete Most cancers Community’s standards for testing, whereas 38 ladies didn’t. Ordinarily, then, these 38 ladies wouldn’t have been examined.

Genetic testing could also be a matter of life or dying

Many ladies who’ve breast most cancers don’t meet the standards underneath the present Nationwide Complete Most cancers Community tips, stated Beitsch, and this impacts their therapy and, probably, their survival.

The most common pre-existing medical conditions
Dr. Otis Brawley, a professor within the division of Hematology and Medical Oncology at Emory College College of Medication, defined that when a affected person with a BRCA 1 or BRCA 2 mutation is identified, “We deal with them otherwise from an individual with no identified mutation.” For instance, surgical choices and the usage of chemotherapy is perhaps based mostly on whether or not a girl has a genetic mutation.

“Over the previous 20 years we’re studying of quite a few genes that may have a mutation. Some change our therapy,” stated Brawley, who was not concerned within the new examine.

Genetic testing, then, isn’t solely essential to a affected person’s survival, Beitsch stated, “but in addition for her members of the family as effectively.” Carrying the identical genetic mutation, a feminine relative could also be at elevated danger for breast most cancers, whereas male family members could also be at elevated danger for prostate and different cancers.

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Dr. Len Lichtenfeld, interim chief medical officer of the American Most cancers Society, stated that “it is a false impression that males can’t be impacted by BRCA genes and it is a false impression that they can’t move them onto their youngsters.”

“There isn’t any query we do not take a look at the individuals we all know ought to be examined,” together with some sufferers with a “household historical past that has most cancers written throughout it. Sadly, too many professionals do not listen,” stated Lichtenfeld, who didn’t contribute to the brand new analysis. One examine, for instance, means that fewer than one in 5 individuals who meet Nationwide Most cancers Complete Community standards and have a historical past of breast most cancers have truly undergone genetic testing.

“Then there’s the group of individuals and not using a household historical past who wish to get examined,” he stated.

Will all of us be routinely examined sooner or later?

A 2016 survey means that greater than half — 56% — of American adults could be concerned with taking a genetic take a look at that indicated the chance of their creating most cancers. The 30 to 64 age group had the best proportion of keen individuals: 63% stated they’d take a most cancers predicting genetic take a look at.
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Regardless of public curiosity and growing information of potential causes of most cancers, insurance policy don’t routinely cowl the expense of medical genetic testing, stated Lichtenfeld. And limitations exist even for individuals who most have to know the outcomes of such assessments, reminiscent of some ladies who’ve been identified with breast most cancers, he stated: “As soon as [a woman] is identified, until she has a household historical past, a whole lot of payers, together with Medicare, won’t pay for the take a look at.”

Some sufferers pay for the testing on their very own, however this isn’t attainable for all sufferers. And a few sufferers could also be unaware of the necessity for medical genetic assessments as a result of the rules don’t advocate they get it.

Body fat levels linked to breast cancer risk in post-menopausal women

Since genetic assessments are actually comparatively cheap, the explanation for creating an “financial roadblock” not exists, Beitsch stated, and so the rules ought to “be wiped.”

“The rules actually do not assist — the truth is, they harm, they injure, they maintain individuals who may benefit from genetic testing from getting it,” stated Beitsch, who hopes the Nationwide Complete Most cancers Community will acknowledge his examine “and take heed of it and hopefully change the rules.”

Lichtenfeld stated most cancers facilities “are discovering many extra individuals who have a hereditary foundation for his or her most cancers than would have been suspected based mostly on our earlier information.” For the reason that human genome was first sequenced in 2003, scientists have develop into more and more adept at studying the mysterious code and what “we do not perceive in the present day, we’ll perceive tomorrow or subsequent yr or within the subsequent decade,” stated Lichtenfeld. He believes that quickly, genetic testing will likely be routine for newborns.

Primarily based on his new analysis, Beitsch cherishes a extra modest hope that on the very least all breast most cancers sufferers will likely be supplied and reimbursed for genetic testing, and maybe, the identical for all most cancers sufferers.

“We’re heading towards a time when all individuals are examined,” he stated. “Mary-Claire King, who found the BRCA 1 and a couple of genes, has referred to as for that.”
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France yellow vest protests: Macron guarantees wage rise – NEWPAPER24

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France yellow vest protests: Macron guarantees wage rise

2018-12-10 19:38:54

Picture copyright Newpaper24

France’s President Emmanuel Macron has promised a minimal wage rise and tax concessions in response to weeks of violent protests.

France has seen 4 weekends of violent protests in opposition to gas tax rises, residing prices and different points.

Talking in a televised tackle to the nation, Mr Macron mentioned that the anger of protesters was “deep, and in some ways professional”.

The minimal wage would improve by 100 euros per thirty days from 2019, he mentioned.

A deliberate tax improve for low-income pensioners could be cancelled, whereas employers could be requested to pay a tax-free finish of 12 months bonus to staff, he added.

Mr Macron, who has till now saved a low profile in the course of the protests, acknowledged that many individuals have been sad with residing situations and felt they “had not been listened to”.

He mentioned that during the last 40 years there had been “a malaise” of “villages and neighbourhoods the place public providers have been diminishing, the place residing situations had deteriorated”.

There have been many “individuals whose standing in society had not been sufficiently nicely recognised. In a cowardly method, we had obtained used to it and the whole lot appeared to recommend that we had forgotten them.

“I assume my Share of the state of affairs – I’ll have given you the sensation I’ve different issues and priorities. I do know a few of you’ve got been harm by my phrases,” he added.

Mr Macron, a former banker, has beforehand been criticised for being out of contact and never listening to the struggles of odd individuals.

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China bans most iPhone gross sales after granting Qualcomm an injunction towards Apple – NEWPAPER24

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China bans most iPhone gross sales after granting Qualcomm an injunction towards Apple

2018-12-10 18:28:15

The ban doesn’t cowl the brand new iPhone XS, iPhone XS Plus or iPhone XR, which weren’t but out there when Qualcomm filed its lawsuit. The telephones coated by the ban make up about 10% to 15% of present iPhone gross sales in China, in response to Daniel Ives, analyst at Wedbush Securities.

The court docket granted a pair of preliminary injunctions requested by Qualcomm, an American microchip maker. Qualcomm claims that Apple violates two of its patents within the iPhone 6S, iPhone 6S Plus, iPhone 7, iPhone 7 Plus, iPhone 8, iPhone Eight Plus and iPhone X. The patents enable individuals to edit and resize photographs on a cellphone and to handle apps through the use of a touchscreen, in response to Qualcomm.

The sensible impact of the injunction is just not but clear. The ruling was introduced publicly Monday however implement final week, however Apple mentioned in a press release that each one iPhone fashions stay out there in China.

“If Apple is violating the orders, Qualcomm will search enforcement of the orders by enforcement tribunals which might be a part of the Chinese language court docket system,” Don Rosenberg, normal counsel for Qualcomm, mentioned in a press release.

Apple accused Qualcomm of enjoying soiled tips, together with asserting a patent that had already been invalidated by worldwide courts, and different patents that it had by no means earlier than used. Apple mentioned it’ll pursue a authorized response in court docket.

“Qualcomm’s effort to ban our merchandise is one other determined transfer by an organization whose unlawful practices are underneath investigation by regulators world wide,” Apple mentioned.

Apple on Monday filed a request for the court docket to rethink its determination. Qualcomm applauded the ruling, saying Apple owes it cash for utilizing its expertise.

“We deeply worth {our relationships} with clients, hardly ever resorting to the courts for help, however we even have an abiding perception in the necessity to shield mental property rights,” Don Rosenberg, normal counsel for Qualcomm, mentioned in a press release. “Apple continues to profit from our mental property whereas refusing to compensate us.”

Traders had been largely unmoved. Apple’s (AAPL) inventory was about flat Monday afternoon. Qualcomm’s (QCOM) inventory rose 2%.

Shock ruling provides to menace of commerce struggle escalation

The ruling was a shock. Product injunctions are hardly ever granted, and China was extensively anticipated to reject Qualcomm’s request for a ban.

Though it is inconceivable to know whether or not politics performed a component within the determination, China and america are embroiled in a tit-for-tat commerce struggle that threatens to boil over.

Days after President Donald Trump and President Xi Jinping agreed on a 90-day commerce truce, Canada introduced that it’s holding for extradition to the US the chief monetary officer of Huawei, China’s greatest telecommunications firm. A bail listening to for the Huawei CFO, Meng Wanzhou, continues Monday.

If the nations cannot come to phrases on an enduring settlement by the tip of the 90-day window, Trump has threatened to impose tariffs on primarily all Chinese language exports to america that aren’t already topic to import taxes.

International battle between tech giants

Apple and Qualcomm are suing each other in courts internationally. Billions of {dollars} are at stake, and either side has claimed some victories.

In 2017, Apple sued Qualcomm for $1 billion after the chipmaker stopped paying for the unique proper to place its chips in iPhones. Qualcomm withheld its funds after the European Union started investigating them. The EU finally deemed the funds unlawful, and In January 2018, the European Fee ordered Qualcomm to pay a $1.2 billion nice over the problem.

Apple and Qualcomm are additionally suing each other in a number of separate patent disputes. Qualcomm has requested a US federal decide to ban the sale of iPhones in a single case. In June, a decide within the Worldwide Commerce Fee discovered that Apple had violated one in all Qualcomm’s patents associated to battery-saving expertise.

In July, Qualcomm mentioned Apple would not embody its modems in iPhones. Qualcomm lower its revenue forecast after the announcement.
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